Androgenetic alopecia is a common kind of hair loss that affects both men and women, but researchers at the University of California, Irvine (UCI) in the United States have found a way to reverse the condition.
SCUBE3, a signaling molecule that binds to a particular receptor, which in this instance is a population of functioning skin units, may be the answer to irreversible hair loss on the scalp, the research suggests. dermal papilla (DP) cells, for short.
The study’s goal was to explain how PD cells, which are fibroblasts that create signals at the base of each hair follicle, stimulate growth, something the researchers previously understood.
Professor of cell biology and research co-author Maksim Plikus said the team’s major finding was that SCUBE3, normally generated by PD cells, “is the message utilized to ‘inform’ nearby hair stem cells to begin to divide, which announces the commencement of new hair development.”
Microinjections of the SCUBE3 protein were used to test the scientists’ theories in mice that had human scalp follicles transplanted into them. New hairs sprang quickly from the latent follicles that had grown in the bald spots. As a result, SCUBE3 is now a prime candidate as a treatment for alopecia.